HIV in Children

TREATMENT OF HERPES SIMPLEX VIRUS (HSV)

Dr. Ira Shah
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Last Updated : 1st September 2012

Drugs

Dosage

Adverse Effects

Remarks

Acyclovir

Neonatal CNS disease

20 mg/kg/dose IV tds x 21 days

Neonatal skin, eye or mouth disease

20 mg/kg/dose IV tds x 14 days

Outside neonatal period - CNS disease

10 mg/kg/dose IV tds x 14 days

Severe gingivostomatitis

5-10 mg/kg/dose IV tds x 14 days

Mild gingivostomatitis & genital herpes

20 mg/kg/day PO tds x 7-14 days (max: 400 mg/dose)

Phlebitis, renal toxicity, nausea, vomiting, rash, neutropenia

Drug of choice for Herpes simplex 1 & 2

Foscarnet

120 mg/kg/d IV in 2-3 divided doses till infection resolves

Renal toxicity, electrolyte abnormalities in calcium, phosphorus, magnesium, potassium, seizures, cardiac arrhythmia's, elevated liver transaminases

Used for acyclovir resistant HSV infection

Valacyclovir

1 gm twice daily PO for 7-10 days for genital herpes in adolescents

Renal toxicity. Other side effects as of acyclovir, nausea, vomiting, thrombotic microangiopathy

Data in children is limited

Famciclovir

500 mg PO BD x 7 days for recurrent mucocutaneous herpes in adolescents

Renal toxicity, GI disturbances, rash, confusion, hallucinations, neutropenia, elevated liver enzymes.

Data limited in children


TREATMENT OF HERPES SIMPLEX VIRUS (HSV)
Dr. Ira Shah
Incharge Pediatric HIV and TB Clinic, B.J.Wadia Hospital for Children, Mumbai, India Consultant in Pediatric Infectious Diseases, Nanavati Hospital, Mumbai, India.
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