HIV in Children

TREATMENT FOR MYCOBACTERIUM TUBERCULOSIS

Dr. Ira Shah
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Last Updated : 1st September 2012

Drugs used for the treatment of Tuberculosis


Drug Dosage Adverse Effects Remarks
INH 5-10 mg/kg /day PO OD. Hepatotoxicity, peripheral neuritis, mild CNS effects Hyper sensitivity reaction. Pyridoxine is recommended in children in all symptomatic HIV disease.
Rifampicin 10-20 mg/kg/day PO OD. Stains urine, tears, sweat, contact lenses and other body fluids orange. GI upset, skin rash, hepatitis, thrombocytopenia, cholestatic jaundice Rifampicin accelerates clearance of PIs & NNRTIs resulting in sub therapeutic levels of the drug
Pyrazinamide 30 mg/kg/day < PO OD Hepatotoxicity, Hyperuricemia, Arthralgia, skin rash, GI intolerance Monthly evaluation of vision is recommended
Ethambutol 15 mg/kg/day PO OD Optic neuritis, colour
blindness, headache,
nausea, peripheral
neuropathy, rash,
hyperuricemia
 
Streptomycin 20-30 mg/kg/day IM Ototoxicity and nephrotoxicity  


TREATMENT FOR MYCOBACTERIUM TUBERCULOSIS
Dr. Ira Shah
Incharge Pediatric HIV and TB Clinic, B.J.Wadia Hospital for Children, Mumbai, India Consultant in Pediatric Infectious Diseases, Nanavati Hospital, Mumbai, India.