ISSN 0973 - 9289

July 2015 NEWSLETTER

Newsletter

2015

July

July 2015 Newsletter

GRAND ROUNDS

A 12 years 10 month old HIV infected boy has been on ART since the age of 2½ years. He has received multiple antiretrovirals in form of zidovudine (AZT), lamivudine (3TC), stavudine (d4T), didanosine (ddI), nevirapine (NVP) and nelfinavir (NFV). His current viral load is 15,000 copies/ml and CD4 count is 595 (17.3%) cells/cumm. His HIV resistance testing showed resistance to NFV and Atazanavir-ritonavir among the protease inhibitors (PI), resistance to NVP and Efavirenz (EFV) among the NNRTI and M41L, E44D, D67N, V75M, V1181, L210W and T215Y mutation suggestive of thymidine analogue mutations (TAMS) leading to high level resistance to abacavir (ABC), AZT, d4T, ddI and intermediate level resistance to tenofovir (TDF) and low level resistance to 3TC and emtricitabine (FTC) among NRTIs. The child was then started on TDF+FTC+Lopinavir-ritonavir (LPVr) and is on regular follow up.

What are thymidine analogue mutations?

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Question Of the Day

A 10 years old female child is newly diagnosed as HIV positive. She has taken ATT 5 yrs back. Her CD4 count is 426. She s asymptomatic for TB. Should we start ART in this child?

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HIV GRAND ROUNDS

A 32 years old HIV infected pregnant female (G2P2L1) presented at 36 weeks of pregnancy for deciding neonatal antiretroviral (ARV) prophylaxis. Her HIV viral load at 34 weeks of gestation was undetectable and she was on antiretroviral therapy (ART) consisting ....

HIV IN CHILDREN APPS